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JNCI Journal of the National Cancer Institute 2001 93(4):319-320;
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 4, 319-320, February 21, 2001
© 2001 Oxford University Press

CORRESPONDENCE

RESPONSE: Re: Multiple Births and Risk of Epithelial Ovarian Cancer

David C. Whiteman, Michael F. G. Murphy, Linda S. Cook, Daniel W. Cramer, Patricia Hartge, Polly A. Marchbanks, Philip C. Nasca, Roberta B. Ness, David M. Purdie, Harvey A. Risch

Affiliations of authors: D. C. Whiteman, D. M. Purdie, Queensland Institute of Medical Research, Brisbane, Australia; M. F. G. Murphy, Imperial Cancer Research Fund General Practice Research Group, University of Oxford, U.K.; L. S. Cook, University of Calgary, Alberta, Canada; D. W. Cramer, Harvard Medical School, Boston, MA; P. Hartge, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD; P. A. Marchbanks, Fertility Epidemiology Section, Centers for Disease Control and Prevention, Atlanta, GA; P. C. Nasca, University of Massachusetts, Amherst; R. B. Ness, University of Pittsburgh, PA; H. A. Risch, Yale University School of Medicine, New Haven, CT.

Correspondence to: David C. Whiteman, M.B., B.S., Ph.D., Population and Clinical Sciences Division, Queensland Institute of Medical Research, P.O. Royal Brisbane Hospital, Herston QLD 4029, Australia (e-mail: daveW{at}qimr.edu.au).

We thank Dr. La Vecchia and co-workers for replicating our analysis in their case–control dataset of Italian women. It is interesting to note that their findings are essentially the same as ours (1). While the point estimate of the relative risk (0.89) in the Italian study was not significantly different from the null, the direction of the association was the same as in seven of the eight studies in our pooled analysis. These independent, confirmatory data, therefore, provide further support for our inference that mothers of twins (and other multiple births) are at reduced risk of ovarian cancer. The question remains as to why this should be so.

REFERENCE

1 Whiteman DC, Murphy MF, Cook LS, Cramer DW, Hartge P, Marchbanks PA, et al. Multiple births and risk of epithelial ovarian cancer. J Natl Cancer Inst 2000;92:1172–7.[Abstract/Free Full Text]cancerlit;20366267


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This Article
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