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JNCI Journal of the National Cancer Institute 1998 90(2):96-97; doi:10.1093/jnci/90.2.96
© 1998 by Oxford University Press
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Side Effects of Prostate Cancer Treatment Are Difficult to Discuss, but Manageable

Although impotence and incontinence may occur after surgery or other treatments for prostate cancer, many physicians shy away from discussing these potential "side effects" with their patients - either because of mutual discomfort, or because the doctor's primary concern is treating a life-threatening disease.

Another factor may be ageism, according to Kate Weaver, a sex therapist and wife of a prostate cancer survivor. She has heard that doctors have said things ranging from "You are older, why are you concerned about sex?" to "Just be happy you are alive."

But quality of life, even for older prostate cancer patients, is emerging as a significant issue in prostate cancer care. "Doctors need to acknowledge this and pay attention to it just as they would [to] a wound," said Arthur Burnett, M.D., a urologist at The Johns Hopkins University in Baltimore.


Otis Brawley, M.D., a medical oncologist at the National Cancer Institute agreed. He said that doctors should be realistic when telling patients about their prior patients' experience.

But existing definitions of incontinence and impotence need exploring, Brawley suggested, because as these words are now defined, they fail to elicit honest answers. Incontinence, for example, which is sometimes medically defined as "needing three or more diapers a day," may be too embarrassing for patients to discuss. And simple yes or no responses to such a definition often hide issues which are problems for the patient, even if they don't exactly fit the definition.

To ensure more accuracy, however, researchers at Johns Hopkins are working on a questionnaire about quality of life issues, touching on such delicate topics as sexual functioning. At least at Hopkins, where nerve-sparing radical prostatectomy was pioneered, said Burnett, "70% of the patients can expect to preserve their sexual functioning." But patients treated elsewhere may not have the same success rates. Radical prostatectomy has shown a 40% to 90% impotence rate with a small percentage of men also being totally incontinent. Radiation treatment results in 40% to 50% impotence.

Not Just Biology

One prostate cancer survivor interviewed for this article said, "As a man, it is damaging to my self esteem [not to be able to perform sexually], even though my partner has been very supportive." His wife, on the other hand, feels that their sex life is better than ever. "Our sex drives are more balanced now and we touch and embrace more in other ways."

Most prostate cancer survivors interviewed for this article felt that while doctors do not need to be experts in sexual issues, they should be able to refer patients to others who are experts. Weaver said that at the time of diagnosis, cancer treatment will take priority, but "the doctor should bring up the subject of sexual issues to show the couple that they can feel comfortable with communicating about the topic and any other issues that may arise later in recovery."

Quality Tenderness

In interviews with men and their wives about their sexual functioning, a common theme was more quality tenderness. "When my husband had a lessened sexual functioning due to prostate cancer, we focused on the hike rather than getting to the top of the mountain," said Weaver.


During a National Institutes of Health writers conference on impotence, survivors, researchers, physicians, and a sex therapist spoke about the realities of this disease, its scope, and treatments. Gavin MacLeod, of the popular television series, "The Love Boat," spoke about his belief that many marriages are terminated due to impotence and said he wants people to know that intimacy is still possible.

MacLeod is also spokesperson for the "Chart A New Course For Your Health" awareness campaign, sponsored by VIVUS, a pharmaceutical company that has developed erectile dysfunction therapies, and the American Foundation for Urologic Disease. The foundation and other organizations are trying to explain to the estimated 20 million men in the United States who suffer from erectile dysfunction that they have options.

There are also new drugs available and being tested for Food and Drug Administration approval. The most innovative are the oral and topical drugs.

Unique Mechanism

One of the most recent oral drugs, sildenafil (Viagra, Pfizer), has a very unique mechanism of action that is focused on the penile erection tissue. In most men, once swallowed, sildenafil will produce an erection within 20-40 minutes if the individual is sexually stimulated. Sildenafil, which does not increase libido or sexual desire, has been submitted for FDA review and it may be approved for patient use by mid-1988.

The National Cancer Institute is sponsoring production of a video for newly diagnosed prostate cancer survivors with a focus on psychological and treatment issues. The video is intended for health care professionals to help their patients work through some of the issues they may face, such as sexual functioning and incontinence. The video is available from State of the Art at 1-800-790-9267.

-- Katie J. Smeltz
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This Article
Right arrow Extract Freely available
Right arrow Alert me when this article is cited
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Right arrow Similar articles in PubMed
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Right arrow Articles by Smeltz, K. J.
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Right arrow Articles by Smeltz, K. J.
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