Journal of the National Cancer Institute Advance Access published online on November 5, 2009
JNCI Journal of the National Cancer Institute, doi:10.1093/jnci/djp403
© The Author 2009. Published by Oxford University Press. All rights reserved.
CORRESPONDENCE |
Response
Affiliations of authors: Department of Pathobiology and Laboratory Medicine, Mount Sinai Hospital and Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, ON, Canada (FO, IA); Department of Medical Oncology, British Columbia Cancer Agency and University of British Columbia, Vancouver, BC, Canada (SC); NCIC Clinical Trials Group, Queen's University, Kingston, ON, Canada (DT, LS); Department of Medical Oncology, McMaster University, Hamilton, ON, Canada (MNL); Department of Medical Oncology, Tom Baker Cancer Centre, Calgary, AB, Canada (VB); Department of Medical Oncology, University of Calgary, Calgary, AB, Canada (VB); Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada (IA); Department of Laboratory medicine and Pathobiology (FPO, ILA), Sunnybrook Odette Cancer Centre, Toronto, ON, Canada (KYIP); Department of Medicine, University of Toronto, Toronto, ON, Canada (KYIP)
Correspondence to: Kathleen I. Pritchard, MD, FRCPC, Sunnybrook Odette Cancer Centre, 2075 Bayview Ave, T2-107, Toronto, ON, Canada M4N 3M5 (e-mail: kathy.pritchard@sunnybrook.ca).
| The first 10% of the full text of this article appears below. |
We are pleased to respond to the letter of Oakman, Moretti, Sotiriou, Viale, and Di Leo regarding our publication (1). We believe, as we stated in the conclusion of this article, that anthracycline benefit is associated with HER2 amplification and with TOP2A alterations. Certainly, our data and those of many others support the relationship between HER2 amplification or overexpression (2), TOP2A alterations (