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Journal of the National Cancer Institute Advance Access published online on November 5, 2009
JNCI Journal of the National Cancer Institute, doi:10.1093/jnci/djp401
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© The Author 2009. Published by Oxford University Press. All rights reserved.

CORRESPONDENCE

Response

Christophe Le Tourneau, J. Jack Lee, Lillian L. Siu

Affiliations of authors: Division of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, ON, Canada (CLT, LLS); Department of Biostatistics, University of Texas M. D. Anderson Cancer Center, Houston, TX (JJL)

Correspondence to: Lillian L. Siu, MD, FRCPC, Division of Medical Oncology and Hematology, Princess Margaret Hospital, University of Toronto, 610 University Ave, Ste 5-718, Toronto, ON, Canada M5G 2M9 (e-mail: lillian.siu@uhn.on.ca).

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We thank Zohar and O'Quigley for their interest in our review on dose escalation methods in phase I cancer clinical trials (1). They communicated concern about the lack of safety using the standard design. They also declared that the continual reassessment method (CRM) outperforms the standard method by more accurately defining the true maximum tolerated dose and by treating more patients at . . . [Full Text of this Article]


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