Journal of the National Cancer Institute Advance Access first published online on November 5, 2009
This version published online on November 9, 2009
JNCI Journal of the National Cancer Institute, doi:10.1093/jnci/djp393
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Published by Oxford University Press 2009.
CORRESPONDENCE |
Response
Affiliation of author: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD
Correspondence to: Mitchell H. Gail, MD, PhD, Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8032, Bethesda, MD 20892-7244 (e-mail: gailm@mail.nih.gov).
| The first 10% of the full text of this article appears below. |
Spitz et al. (1) showed that adding three single-nucleotide polymorphisms (SNPs) improved the discriminatory accuracy of a risk model for lung cancer that included clinical and epidemiological risk factors. In particular, the area under the receiver operating characteristic curve (AUC) increased statistically significantly from 0.661 to 0.673. Spitz et al. rightly looked for