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Journal of the National Cancer Institute Advance Access originally published online on October 28, 2009
JNCI Journal of the National Cancer Institute 2009 101(22):1592-1593; doi:10.1093/jnci/djp356
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© The Author 2009. Published by Oxford University Press.

CORRESPONDENCE

Re: Antitumor Efficacy Testing in Rodents

Italo Poggesi, Giuseppe de Nicolao, Massimiliano Germani, Maurizio Rocchetti

Affiliations of authors: Clinical Pharmacology Modeling & Simulation Unit, GlaxoSmithKline, Verona, Italy (IP); Dipartimento di Informatica e Sistemistica, University of Pavia, Pavia, Italy (GdN); Prediction & Modeling Unit, Accelera S.R.L. Company, Nerviano (MI), Italy (MG, MR)

Correspondence to: Italo Poggesi, Clinical Pharmacology Modeling & Simulation, GlaxoSmithKline, Via Fleming 4, Verona 37135, Italy (e-mail: italo.2.poggesi@gsk.com).

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In her thorough commentary, Hollingshead (1) discussed the key to successfully conducting in vivo antitumor efficacy testing in rodent models. She identified as crucial the appropriate choice of different items, such as tumor models, experimental conditions, dosing regimens, experimental endpoints, and statistics for comparing experimental groups. We agree that the adoption of standardized experimental conditions increases the . . . [Full Text of this Article]


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