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Journal of the National Cancer Institute Advance Access published online on September 9, 2009
JNCI Journal of the National Cancer Institute, doi:10.1093/jnci/djp311
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© The Author 2009. Published by Oxford University Press.

EDITORIAL

An Iatrogenic Confounding Variable

Peter C. Albertsen

Affiliation of author: Department of Surgery (Urology), University of Connecticut Health Center, Farmington, CT

Corresponding author: Peter C. Albertsen, MD, MS, Department of Surgery (Urology), University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030-3955 (e-mail: albertsen@nso.uchc.edu).

The first 10% of the full text of this article appears below.

Why do some men develop clinically significant prostate cancer whereas others do not? Epidemiologists have pondered this dilemma for decades. During this time, we have learned that many men harbor incidental prostate cancers, some even as young as 30 years, but that most men will not develop clinically significant disease (1,2). Careful examination of racial patterns of disease progression has taught us that environmental factors play a major role in the development of clinically significant disease. Prostate cancers, for example, are relatively rare among Asians living in China and Japan but are more common among Asians who . . . [Full Text of this Article]


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J Natl Cancer Inst 2009 101: 1365. [Extract] [Full Text] [PDF]