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Journal of the National Cancer Institute Advance Access published online on February 10, 2009
JNCI Journal of the National Cancer Institute, doi:10.1093/jnci/djp013
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© Oxford University Press 2009.

NEWS

Can Game Theory Explain Invasive Tumor Metabolism?

Mike Martin

The first 150 words of the full text of this article appear below.

Game theory, the discipline behind the Oscar-winning film A Beautiful Mind and the science that predicts strategies and payoffs in competitive scenarios, may explain how invasive cancer cells gain the upper hand in certain metabolic scenarios.

For a report published in the December 2008 issue of Cell Proliferation, German researchers Andreas Deutsch, Ph.D., and Haralambos Hatzikirou, Ph.D., from the Dresden University of Technology, and colleagues studied how tumor cells compete in the survival game.


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  		Andreas Deutsch, M.D.

 
Applying the tools of game theory to low-grade glioma growth, Deutsch and his team found that in a tumor populated by glycolytic cells, invasive cells have a better chance of emerging. They conclude that the findings may explain invasive growth under otherwise nonmalignant circumstances, and they suggest anti-invasive therapeutics.

"To the best of our knowledge, ours is the first attempt to use game theory to analyze the interplay of different tumor . . . [Full Text of this Article]

Mathematical Oncology

Survival Savvy

Costs and Payoffs

Clinical Implications?


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