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Journal of the National Cancer Institute Advance Access published online on November 25, 2008
JNCI Journal of the National Cancer Institute, doi:10.1093/jnci/djn413
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© The Author 2008. Published by Oxford University Press.

EDITORIALS

Lymphadenectomy's Role in Early Endometrial Cancer: Prognostic or Therapeutic?

Christine S. Walsh, Beth Y. Karlan

Affiliations of authors: Women's Cancer Research Institute, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA (CSW, BYK)

Correspondence to: Beth Y. Karlan, Women's Cancer Research Institute, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, #290W, Los Angeles, CA 90048 (e-mail: karlanb@cshs.org).

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In 1988, endometrial cancer became a surgically staged disease. Because frequent inaccuracies in clinical staging were recognized, the International Federation of Gynecology and Obstetrics introduced a new surgicopathologic staging system that emphasized the prognostic value of surgical staging information (1). Largely on the basis of the seminal findings of the Gynecologic Oncology Group (GOG) 33 trial (2), surgical staging was introduced that incorporated pathological risk factors to better define the extent of disease, estimate prognosis, and guide adjuvant treatment recommendations. Despite implementation of this more accurate staging system, optimal treatment for the management of endometrial cancer remains controversial, particularly in patients with intermediate-risk disease, which . . . [Full Text of this Article]


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