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Journal of the National Cancer Institute Advance Access published online on November 11, 2008
JNCI Journal of the National Cancer Institute, doi:10.1093/jnci/djn390
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© The Author 2008. Published by Oxford University Press.

EDITORIALS

Breast Cancer Prevention Using Calcium and Vitamin D: A Bright Future?

Corey Speers, Powel Brown

Affiliations of authors: Department of Molecular and Cellular Biology (CS), Lester and Sue Smith Breast Center and Department of Medicine (PB), Baylor College of Medicine, Houston, TX

Correspondence to: Powel H. Brown, MD, PhD, Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, BCM 600, Houston, TX 77030 (e-mail: pbrown@breastcenter.tmc.edu).

The first 150 words of the full text of this article appear below.

Despite aggressive treatment and screening efforts, breast cancer remains the second leading cause of cancer-related deaths among women in the United States (1). Because of the large number of women dying from this disease and the toxicity of breast cancer treatments, recent efforts have focused on identifying effective cancer preventive agents. These efforts have led to the development of antiestrogen agents, such as tamoxifen and raloxifene, which prevent approximately 50% of invasive breast cancers in women who are at high risk for breast cancer. However, the use of these agents for breast cancer prevention has been limited by their toxicity.

A large amount of evidence exists to indicate that vitamin D may be a particularly promising cancer preventive agent. Vitamin D is a fat-soluble vitamin that is essential for bone formation and calcium homeostasis. The potential link between vitamin D levels and reduced cancer incidence was suggested by . . . [Full Text of this Article]


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A. Olsen, R. Egeberg, and A. Tjonneland
Re: Calcium Plus Vitamin D Supplementation and the Risk of Breast Cancer
J Natl Cancer Inst, May 6, 2009; 101(9): 690 - 690.
[Full Text] [PDF]