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Results from Adjuvant Breast Cancer Randomized Trials
Patients with early-stage breast cancer have an improved outcome after a single treatment with tamoxifen, ovarian ablation or suppression, or chemotherapy. The Adjuvant Breast Cancer Trials were initiated to determine whether 5 years of tamoxifen treatment, combined with chemotherapy and/or ovarian ablation or suppression, would further improve outcomes. In the chemotherapy trial reported by Bliss et al. (p. 506), 1,991 women with early-stage breast cancer were randomly assigned between 1992 and 2000 to receive chemotherapy. The women could have undergone ovarian ablation or suppression or not. The addition of
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J Natl Cancer Inst 2007 99: 494-495.
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