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JNCI Journal of the National Cancer Institute 2007 99(6):418-419; doi:10.1093/jnci/djk124
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© The Author 2007. Published by Oxford University Press.

EDITORIALS

Fat Intake and Breast Cancer Revisited

Stephanie A. Smith-Warner, Meir J. Stampfer

Affiliations of authors: Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA (SASW, MJS); Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (MJS)

Correspondence to: Meir J. Stampfer, MD, PhD, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, 3rd Fl, Boston, MA 02115 (e-mail: mstampfe@hsph.harvard.edu).

The first 10% of the full text of this article appears below.

The relationship between dietary fat and the risk of breast cancer has been controversial for decades. Early international correlation studies (1), buttressed by later case–control studies (2), suggested a positive relationship. However, the substantial confounding in the international correlation studies by many factors—especially reproductive variables—and the potential for recall and selection biases in retrospective studies cast doubt on those results. Indeed, most prospective studies (2), including two large pooled analyses of prospective studies (3,4), have not demonstrated a link between fat intake and breast cancer risk.

However, several recent cohort studies have reported results that suggest a modest positive . . . [Full Text of this Article]


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