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JNCI Journal of the National Cancer Institute 2007 99(4):261-263; doi:10.1093/jnci/djk077
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© The Author 2007. Published by Oxford University Press.

EDITORIALS

Toward a Consensus in Molecular Diagnosis of Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome)

Henry T. Lynch, Jane F. Lynch, Patrick M. Lynch

Affiliations of authors: Department of Preventive Medicine, Creighton University School of Medicine, Omaha, NE (HTL, JFL); Department of Gastrointestinal Medicine and Nutrition, The University of Texas M. D. Anderson Cancer Center, Houston, TX (PML)

Correspondence to: Henry T. Lynch, MD, Department of Preventive Medicine, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178 (e-mail: htlynch@creighton.edu).

The first 150 words of the full text of this article appear below.

Before molecular genetic diagnostics came of age in the 1990s, a comprehensive family history was the only basis on which familial risk of colorectal cancer could be estimated. In the case of hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, the historic perspective offered by Warthin in 1895 has not changed appreciably (1). Warthin's seamstress confided to him that one day she would die of cancer of the colon or of the female organs, "because everyone in my family died of these diseases." Her prophecy proved accurate because she died of endometrial cancer at a relatively young age. In 2007, many patients still base their expectations and plan their behaviors around a similar sense of fatalism, and little else.

The seamstress's family, now known as family G, was subsequently updated (2) following the report of two strikingly similar families, which, for the lack of . . . [Full Text of this Article]


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H. T. Lynch, C. R. Boland, M. A. Rodriguez-Bigas, C. Amos, J. F. Lynch, and P. M. Lynch
Who Should Be Sent for Genetic Testing in Hereditary Colorectal Cancer Syndromes?
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