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JNCI Journal of the National Cancer Institute 2007 99(3):186-187; doi:10.1093/jnci/djk058
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© The Author 2007. Published by Oxford University Press.

EDITORIAL

An Affair of the Heart

John D. Boice, Jr

Affiliations of author: International Epidemiology Institute, Rockville, MD, and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN

Correspondence to: John D. Boice Jr, ScD, International Epidemiology Institute, 1455 Research Blvd., Ste. 550, Rockville, MD 20850 (e-mail: john.boice@vanderbilt.edu).

The first 10% of the full text of this article appears below.

In 1950, patients with Hodgkin lymphoma had a median survival time of 4 years and a 5-year relative survival rate of 29% (1). Since the introduction of radiation therapy and chemotherapy for Hodgkin lymphoma in the 1960s and 1970s, the 5-year relative survival rate is more than 85% (2), and these patients can now expect a long lymphoma-free life. However, the price for this phenomenal success has been high. "Radiation-induced heart disease" was recognized in the 1960s (3) and radiation-induced cancers somewhat later (4–6). Multidrug chemotherapy was introduced in the 1970s . . . [Full Text of this Article]


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