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Journal of the National Cancer Institute Advance Access originally published online on December 11, 2007
JNCI Journal of the National Cancer Institute 2007 99(24):1830-1832; doi:10.1093/jnci/djm284
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© Oxford University Press 2007.

NEWS

Lung Cancer May Be Different for Men and Women, But Researchers Ponder What To Do?

Karyn Hede

The first 150 words of the full text of this article appear below.

Researchers have known for many years that lung cancer manifests itself differently in men and women. Several studies have determined that women with the same level of disease live longer than men, and many underlying biological differences have been posited to explain this difference.

Now several new studies indicate that estrogen is a key player. In light of the evidence, a National Cancer Institute–funded clinical trial is under way that will prospectively look at the role of estrogen levels and carcinogen metabolism in the outcomes of lung cancer patients. Also, the U.S. Food and Drug Administration recently approved the first lung cancer clinical trial specifically designed to test whether women with higher estrogen levels metabolize an experimental chemotherapy agent differently than women with lower estrogen levels. It could represent a first step toward personalized therapeutic regimens for women with lung cancer.

Since the early 1980s, the number of women developing . . . [Full Text of this Article]

Early Estrogen Influence

What Now?


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