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Correction for Garber, J. Natl. Cancer Inst. 98 (13) 885-887.

Journal of the National Cancer Institute Advance Access originally published online on November 13, 2007
JNCI Journal of the National Cancer Institute 2007 99(22):1664-1665; doi:10.1093/jnci/djm242
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© Oxford University Press 2007.

NEWS

BIG JOB FOR LITTLE RNAs

MicroRNAs Found Cavorting With p53

Mary Beckman

The first 10% of the full text of this article appears below.

The tumor suppressor protein p53 has long held the spotlight as master of ceremonies in the meteoric rise of malignancies. Now, a class of small RNAs that has been waiting in the wings appears poised to take center stage—or at least dance backup.

Over the last several years, more and more of the small RNAs called microRNAs have been uncovered performing a variety of duties in cancer (see J Natl Cancer Inst 2006;98:885–7). Now, several research groups have unearthed microRNAs working with one of the most infamous players in cancer biology: tumor suppressor p53.

The finding comes as no surprise, given the number of microRNAs being found in cells. "We expected that some of the targets of such a prominent transcription factor . . . [Full Text of this Article]


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