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Correction for Tamimi et al., J. Natl. Cancer Inst. 99 (15) 1178-1187.
Correction for Barlow et al., J. Natl. Cancer Inst. 98 (17) 1204-1214.
Correction for Chen et al., J. Natl. Cancer Inst. 98 (17) 1215-1226.

Journal of the National Cancer Institute Advance Access originally published online on November 13, 2007
JNCI Journal of the National Cancer Institute 2007 99(22):1661-1663; doi:10.1093/jnci/djm243
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© Oxford University Press 2007.

NEWS

Dense Breasts Linked to Higher Breast Cancer Risk, But Clinicians Unsure of Application

Renee Twombly

The first 150 words of the full text of this article appear below.

High breast density is emerging as one of the strongest risk factors for breast cancer, and not just because thick tissue can mask small tumors on a mammogram.

A spate of recent studies have shown that density—the amount of epithelial tissue and connective tissue relative to fat—is an independent risk factor for breast cancer, topped only by age and the rare breast cancer susceptibility genes BRCA1 and BRCA2. The research suggests that about a third of breast cancers are related to high breast density. Having breasts that are made up primarily of dense breast tissue increases breast cancer risk by up to fivefold, compared with a woman with little dense breast tissue.

The idea that breast density is related to breast cancer risk is not new. It was first postulated in 1976 by Detroit hospital radiologist John Wolfe, M.D., who speculated that women with the densest breasts may be more . . . [Full Text of this Article]

Short-term Mask, Long-term Risk

Hormones Not to Blame

Trait in the Genes

Acting on Risk


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