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JNCI Journal of the National Cancer Institute 2007 99(22):1653; doi:10.1093/jnci/djm239
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© Oxford University Press 2007.

IN THIS ISSUE

The first 10% of the full text of this article appears below.

Indentification of New Tumor Suppressor Gene for Lung Cancer

Many genetic and epigenetic changes are usually necessary for lung cancers to develop, including the inactivation of tumor suppressor genes. The human G protein-coupled receptor C type 5A (GPRC5A) gene is expressed at higher levels in normal lung cells than in lung tumor cells. To find out whether it is a tumor suppressor, Tao et al. (p. 1668) developed a knockout mouse model and compared GPRC5A expression in normal human lung tissues and lung cancers. The Gprc5A knockout mice developed more lung tumors (76% developed adenomas and 17% adenocarcinomas) than the wild-type mice (10% developed adenomas) during . . . [Full Text of this Article]

Molecular Basis for ER{alpha} Deficiency in BRCA1-Linked Breast Cancer

Ultrasound versus CA-125 for the Diagnosis of Adnexal Masses

Predicting Breast Cancer Risk by Hormone Receptor Status

Challenges in Assigning Patients to Previously Identified Subtypes

Amelioration of ZD6126-Induced Cardiac Toxicity in Rats

Possible Association Between Smoking and Rectal Cancer


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