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Journal of the National Cancer Institute Advance Access originally published online on October 30, 2007
JNCI Journal of the National Cancer Institute 2007 99(21):1568-1570; doi:10.1093/jnci/djm220
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© Oxford University Press 2007.

NEWS

ENCODE Exposure?

Newly Revealed Genome Complexity May Mean Personalized Medicine Is Farther Away

Charlie Schmidt

The first 150 words of the full text of this article appear below.

A global effort to find all the functional elements in DNA has revealed surprising genomic complexity that will probably complicate progress toward personalized medicine.

The findings suggest that enormous regions of the genome once dubbed "junk DNA" are functional, even though they don’t code for proteins. The discovery—described in Nature in June and detailed in 28 companion reports in the June issue of Genome Research—was made by the ENCODE (Encyclopedia of DNA Elements) consortium, a collection of 35 research groups from around the world headed by the National Human Genome Research Institute (NHGRI) at the National Institutes of Health.

ENCODE scientists exhaustively studied 30 million base pairs of human DNA, about 1% of the genome, and found evidence of transcription in the regions that lie between individual genes. (Transcription is the process by which DNA makes RNA, the molecule from which proteins are generated.) Scientists used to think that . . . [Full Text of this Article]

Complexity Poses New Challenges

Reality Versus Expectations


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 The Annals of PharmacotherapyHome page
C. E Dean
Personalized Medicine: Boon or Budget-Buster?
Ann. Pharmacother., May 1, 2009; 43(5): 958 - 962.
[Abstract] [Full Text] [PDF]