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Journal of the National Cancer Institute Advance Access originally published online on October 9, 2007
JNCI Journal of the National Cancer Institute 2007 99(20):1499-1501; doi:10.1093/jnci/djm186
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Published by Oxford University Press 2007.

EDITORIALS

The Evidence for Prostate Cancer Risk Loci at 8q24 Grows Stronger

Sharon A. Savage, Mark H. Greene

Affiliation of authors: Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD

Correspondence to: Sharon A. Savage, MD, Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS-7018, Rockville, MD 20892 (e-mail: savagesh@mail.nih.gov).

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Genetic association studies that implicate chromosome 8q24 polymorphisms as risk factors for cancer are appearing at an astounding rate. Chromosomal band 8q24 became a genomic region of interest when two separate studies (1,2) reported that markers within a 1-Mb region (127.9–128.0 Mb) at this locus are statistically significantly associated with an increased risk of prostate cancer. With astonishing speed, multiple studies replicated and/or found similar results in the same region (3–9) (Table 1). The designs of these studies included genotyping of single-nucleotide polymorphisms (SNPs) in the predefined 8q24 region (5–9) and genome-wide association studies (3,4). Some of the studies replicated published findings for the same specific SNPs, while others found associations in . . . [Full Text of this Article]


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