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JNCI Journal of the National Cancer Institute 2007 99(2):99-100; doi:10.1093/jnci/djk025
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© The Author 2007. Published by Oxford University Press.

EDITORIAL

Calcium Supplementation and Prevention of Colorectal Neoplasia: Lessons From Clinical Trials

María Elena Martínez, Elizabeth T. Jacobs

Affiliations of authors: Arizona Cancer Center, and Mel and Enid Zuckerman College of Public Health, The University of Arizona, Tucson, AZ

Correspondence to: María Elena Martínez, PhD, Arizona Cancer Center, 1515 North Campbell Ave., Tucson, AZ 85724-5024 (e-mail: emartinez@azcc.arizona.edu).

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Dietary calcium has long been implicated as a protective factor for colorectal cancer and adenomas. Investigation of this nutrient was triggered by mechanisms proposed in the early 1980s based on in vivo and in vitro studies (1,2). Fast-forward to more than 20 years later, and we find ourselves debating the importance of this nutrient in the etiology of colorectal neoplasia. Examination of the abundant amount of observational data is a worthwhile exercise. Although some inconsistencies are evident across studies, the picture that emerges from most prospective studies of colorectal cancer and calcium intake suggests a threshold effect . . . [Full Text of this Article]


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