Skip Navigation

JNCI Journal of the National Cancer Institute 2007 99(18):1353; doi:10.1093/jnci/djm161
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Japanese Translation
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Search for Related Content
Related Collections
Right arrowRelated Articles in JNCI

© Oxford University Press 2007.
The first 10% of the full text of this article appears below.

High-Grade Prostate Cancer, Prostate Volume, and Finasteride

The Prostate Cancer Prevention Trial (PCPT) reported that patients taking finasteride, a 5{alpha}-reductase inhibitor, had a decreased incidence of prostate cancer overall. However, the incidence of high-grade cancer was higher in the finasteride group than the placebo group. One possible explanation for this increase is that finasteride induces high-grade tumors, but several other mechanisms could also explain it.

To investigate whether the increase could be due to finasteride's influence on prostate volume or tumor morphology, Lucia et al. (p. 1375) examined prostate biopsy samples from PCPT participants with high Gleason scores for hormonal effects and pathologic . . . [Full Text of this Article]

Cancer Mortality in the United States by Education and Race

Cancer Yield of Prostate Biopsies Prompted by PSA Screening

Lung Cancer Survival and Functional Polymorphisms in MBL2

Oncolytic Adenovirus Delta-24-RGD and Brain Tumor Stem Cells


Related Articles in JNCI

Examination of the Therapeutic Potential of Delta-24-RGD in Brain Tumor Stem Cells: Role of Autophagic Cell Death
Hong Jiang, Candelaria Gomez-Manzano, Hiroshi Aoki, Marta M. Alonso, Seiji Kondo, Frank McCormick, Jing Xu, Yasuko Kondo, B. Nebiyou Bekele, Howard Colman, Frederick F. Lang, and Juan Fueyo
J Natl Cancer Inst 2007 99: 1410-1414. [Abstract] [Full Text] [PDF]

Finasteride and High-Grade Prostate Cancer in the Prostate Cancer Prevention Trial
M. Scott Lucia, Jonathan I. Epstein, Phyllis J. Goodman, Amy K. Darke, Victor E. Reuter, Francisco Civantos, Catherine M. Tangen, Howard L. Parnes, Scott M. Lippman, Francisco G. La Rosa, Michael W. Kattan, E. David Crawford, Leslie G. Ford, Charles A. Coltman, Jr, and Ian M. Thompson
J Natl Cancer Inst 2007 99: 1375-1383. [Abstract] [Full Text] [PDF]

Detection of Prostate Cancer via Biopsy in the Medicare–SEER Population During the PSA Era
H. Gilbert Welch, Elliott S. Fisher, Daniel J. Gottlieb, and Michael J. Barry
J Natl Cancer Inst 2007 99: 1395-1400. [Abstract] [Full Text] [PDF]

Cancer Mortality in the United States by Education Level and Race
Jessica D. Albano, Elizabeth Ward, Ahmedin Jemal, Robert Anderson, Vilma E. Cokkinides, Taylor Murray, Jane Henley, Jonathan Liff, and Michael J. Thun
J Natl Cancer Inst 2007 99: 1384-1394. [Abstract] [Full Text] [PDF]

Lung Cancer Survival and Functional Polymorphisms in MBL2, an Innate-Immunity Gene
Sharon R. Pine, Leah E. Mechanic, Stefan Ambs, Elise D. Bowman, Stephen J. Chanock, Christopher Loffredo, Peter G. Shields, and Curtis C. Harris
J Natl Cancer Inst 2007 99: 1401-1409. [Abstract] [Full Text] [PDF]

Detection Bias Due to the Effect of Finasteride on Prostate Volume: A Modeling Approach for Analysis of the Prostate Cancer Prevention Trial
Yael C. Cohen, Kenneth S. Liu, Norman L. Heyden, Alexandra D. Carides, Keaven M. Anderson, Anastasia G. Daifotis, and Peter H. Gann
J Natl Cancer Inst 2007 99: 1366-1374. [Abstract] [Full Text] [PDF]

High-Grade Prostate Cancer in the Prostate Cancer Prevention Trial: Fact or Artifact?
Gerald L. Andriole, Peter A. Humphrey, Robert J. Serfling, and Robert L. Grubb
J Natl Cancer Inst 2007 99: 1355-1356. [Extract] [Full Text] [PDF]

Untangling Differences in Cancer Mortality Rates: A Closer Look at Race and Education
Sholom Wacholder
J Natl Cancer Inst 2007 99: 1356-1357. [Extract] [Full Text] [PDF]