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Journal of the National Cancer Institute Advance Access originally published online on August 28, 2007
JNCI Journal of the National Cancer Institute 2007 99(17):1288-1289; doi:10.1093/jnci/djm146
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© Oxford University Press 2007.

NEWS

Pregnancy Problem Yields Insight Into Cancer Drug–Induced High Blood Pressure

Mary Beckman

The first 10% of the full text of this article appears below.

Blood vessel growth, or angiogenesis, is a popular target in cancer therapies these days. After all, cancers need blood to grow, so cutting off their supply can choke them to death. Three approved, effective drugs all inhibit the same key molecule that simulates angiogenesis, but they all seem to have a similar side effect: high blood pressure.

No one is sure how these drugs cause high blood pressure, but research in renal cancer and a pregnancy complication called preeclampsia offers one intriguing hypothesis. Women with preeclampsia have dangerously high blood pressure, and renal cancer biologist Vikas Sukhatme, M.D., Ph.D., at Beth Israel Deaconess Medical Center in Boston suggests that the cancer drugs cause high blood pressure in the same way that it does in some pregnant . . . [Full Text of this Article]

Hypertension Risk Factor

Clamping Down on VEGF

Getting Along


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