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JNCI Journal of the National Cancer Institute 2007 99(13):981; doi:10.1093/jnci/djm054
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© Oxford University Press 2007.

IN THIS ISSUE

The first 10% of the full text of this article appears below.

Defining Endpoints in Trials of Colon Cancer Adjuvant Treatment

Many different outcomes are used as the primary endpoint of trials testing adjuvant treatments in cancer. The use of different endpoints—which may be defined differently by different investigators—in a single cancer type can make it difficult to compare the results of different studies. Punt et al. (p. 998) examined the endpoints and endpoint definitions used in published phase III clinical trials of adjuvant treatment for colon cancer over the last decade. A total of 52 studies were identified that used eight endpoints, most commonly disease-free survival, in addition to overall survival. Many endpoints were defined in multiple ways; . . . [Full Text of this Article]

Nanocarriers and Drug Toxicity, Effectiveness

Intravenous Bisphosphonate Therapy and Jaw Complications

Sexual Function Among Men in the Prostate Cancer Prevention Trial

New Trial Design for Treatment in Biomarker-Defined Groups

Early-Stage Breast Cancer Rates and Sentinel Lymph Node Biopsy


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