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Classification of NSCLC Patients for EGFR Inhibitor Benefits
Only a subset of patients with nonsmall-cell lung cancer (NSCLC) respond to gefitinib and erlotinib, small-molecule tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR), but a larger fraction appear to have prolonged stabilization of disease. Taguchi et al. (p. 838) investigated whether mass spectrometic features in pretreatment blood serum might be used to classify NSCLC patients according to their outcomes after treatment with these drugs. To do so, they developed a matrix-assisted laser desorption/ionization (MALDI) algorithm from a training set of patients with known outcomes. They tested the algorithm on two independent validation cohorts. In
Comparing Cisplatin, Carboplatin for Treatment of Advanced NSCLC
Proteomic Signature and Outcome in Patients with NSCLC
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Aspirin, Nonaspirin NSAIDs, and Cancer Incidence and Mortality
Inflammation, C-Reactive Protein, and Breast Cancer Risk
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