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JNCI Journal of the National Cancer Institute 2006 98(9):576-577; doi:10.1093/jnci/djj199
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© Oxford University Press 2006.

NEWS

CAMs Are Stopping Cancer in Its Metastatic Tracks

Mary Beckman

The first 10% of the full text of this article appears below.

A counterintuitive idea is making the rounds in cancer research: Stickiness promotes mobility. Proteins that help cells stick together, called cellular adhesion molecules (CAMs), may be a driving force in metastasis, and they seem to be present in almost every cancer tested. The good news is that blocking CAMs seems to slow the spread of cancer.

In fact, using antibodies to interfere with CAMs is promising enough to warrant a clinical trial, according to Peter Altevogt, Ph.D., at the German Cancer Research Center in Heidelberg, where a phase I trial is planned. "Since the situation with tumor patients is so disastrous, it's exciting," he said. "Antibody-based therapy bears a lot of hope and expectation."


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  		Peter Altevogt

 
But researchers are also trying to understand the underlying biology—what the CAMs do on the surface in the first place, whether they transfer biochemical signals from the surface to the cell's interior, . . . [Full Text of this Article]

L1 Antibodies

The Back Story


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