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© Oxford University Press 2006.
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Researchers Target Unfolded Protein Response in Cancerous Tumor Growth
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Cancer cells, in their relentless drive to survive, hijack many normal processes: cell cycle signaling, angiogenesis, glucose metabolism, cell death, multidrug resistance. In the last few years, researchers have shown how another cell survival mechanism—the unfolded protein response, or UPR—might also belong on the list.
"We think it's going to be really important in the context of tumor growth," said Alan Diehl, Ph.D., of the University of Pennsylvania in Philadelphia. Recently, groups at Stanford University in Palo Alto, Calif., and Wake Forest University in Winston-Salem, N.C., have shown that tumors depend on an intact UPR for growth. And studies of a drug used for multiple myeloma, bortezomib (Velcade), strongly suggest that it kills tumors by causing stress in the cell while inhibiting part of the UPR. These and other studies have sparked a surge of interest in the UPR in cancer, as well as in other diseases.
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Cracking the UPR Code
The Cancer Connection
Targeting the UPR
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