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JNCI Journal of the National Cancer Institute 2006 98(7):439-440; doi:10.1093/jnci/djj148
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© Oxford University Press 2006.

NEWS

Accrual Delayed in Adjuvant Bevacizumab Trial

Rabiya S. Tuma

The first 10% of the full text of this article appears below.

Researchers have temporarily halted accrual to a trial of bevacizumab (Avastin) and two chemotherapy regimens for early-stage colon cancer after they found an unexpected number of non-cancer-related deaths in one of the study arms. The data safety monitoring board (DSMB) recommended that enrollment be delayed until 60-day mortality data could be collected and reviewed for all patients currently in the study. Experts say that the imbalance in deaths is likely to be a statistical anomaly, but . . . [Full Text of this Article]


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