© Oxford University Press 2006.
IN THIS ISSUE
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Redox Modulators and Anticancer Drug Activity
Mangafodipir, a contrast agent used in magnetic resonance imaging, modifies the production of reactive oxygen species in ways that could prove useful for cancer therapy. As a superoxide dismutase mimic, it catalyzes the production of hydrogen peroxide, which is toxic to cancer cells. Via its catalase and glutathione reductase activities it can protect normal cells from death induced by reactive oxygen species, whose intracellular levels increase after treatment with anticancer drugs. In this issue (p. 236), Alexandre et al. examined the effect of mangafodipir on anticancer drug activity and cytotoxicity against both normal and cancer cells. Mangafodipir protected
Antioxidant Vitamins and Prostate Cancer Risk
Gene Methylation in Tumor-Associated Normal Cells
Breast Cancer Grade and Gene Expression Profiling
Darbepoetin Alfa Treatment Every 3 Weeks
MDM2 SNP, p53 Status, and Colorectal Cancer Onset