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JNCI Journal of the National Cancer Institute 2006 98(4):221; doi:10.1093/jnci/djj082
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© Oxford University Press 2006.

IN THIS ISSUE

The first 10% of the full text of this article appears below.

Redox Modulators and Anticancer Drug Activity

Mangafodipir, a contrast agent used in magnetic resonance imaging, modifies the production of reactive oxygen species in ways that could prove useful for cancer therapy. As a superoxide dismutase mimic, it catalyzes the production of hydrogen peroxide, which is toxic to cancer cells. Via its catalase and glutathione reductase activities it can protect normal cells from death induced by reactive oxygen species, whose intracellular levels increase after treatment with anticancer drugs. In this issue (p. 236), Alexandre et al. examined the effect of mangafodipir on anticancer drug activity and cytotoxicity against both normal and cancer cells. Mangafodipir protected . . . [Full Text of this Article]

Antioxidant Vitamins and Prostate Cancer Risk

Gene Methylation in Tumor-Associated Normal Cells

Breast Cancer Grade and Gene Expression Profiling

Darbepoetin Alfa Treatment Every 3 Weeks

MDM2 SNP, p53 Status, and Colorectal Cancer Onset


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