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JNCI Journal of the National Cancer Institute 2006 98(24):1755-1757; doi:10.1093/jnci/djj505
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© The Author 2006. Published by Oxford University Press.

EDITORIAL

Cancer Stem Cells and Radiotherapy: New Insights Into Tumor Radioresistance

Maximilian Diehn, Michael F. Clarke

Affiliations of authors: Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA (MD); Stanford Institute for Stem Cell Biology and Regenerative Medicine, Palo Alto, CA (MD, MFC)

Correspondence to: Maximilian Diehn, MD, PhD, Department of Radiation Oncology, Stanford University School of Medicine, 875 Blake Wilbur Dr., MC-5847, Stanford, CA 94305 (e-mail: diehn@stanford.edu).

The first 150 words of the full text of this article appear below.

Solid tumors are histologically heterogeneous and include tumor cells, stroma, inflammatory infiltrates, and vascular structures. Furthermore, it has long been recognized that subpopulations of cancer cells exist within the tumors that resemble the developmental hierarchy of the normal tissue from which the tumor arose. In recent years, the cancer stem cell model of tumorigenesis has received increasing attention. This model posits that tumors are driven and maintained by a minority subpopulation of cells that have the capacity to self-renew (i.e., give rise to progeny with similar properties as themselves) and to generate the more differentiated progeny which make up the bulk of a tumor (1). The former population has been termed cancer stem cells (CSCs), tumorigenic cancer cells, or tumor-initiating cells, by various investigators, to indicate that only they can give rise to new tumors when transplanted into immunodeficient animals.

Evidence for the existence of CSCs initially . . . [Full Text of this Article]


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