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JNCI Journal of the National Cancer Institute 2006 98(24):1753-1755; doi:10.1093/jnci/djj504
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© The Author 2006. Published by Oxford University Press.

EDITORIAL

Dietary Fat and Breast Cancer: Contributions From a Survival Trial

Anne C. M. Thiébaut, Arthur Schatzkin, Rachel Ballard-Barbash, Victor Kipnis

Affiliations of authors: Divisions of Cancer Epidemiology and Genetics (ACMT, AS), Cancer Control and Population Sciences (RBB), and Cancer Prevention (VK), National Cancer Institute, Bethesda, MD

Correspondence to: Victor Kipnis, PhD, Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd., EPN 3124, Bethesda, MD 20892 (e-mail: kipnisv@mail.nih.gov).

The first 10% of the full text of this article appears below.

The relation between dietary fat and breast cancer incidence and survival remains one of the most controversial hypotheses in nutritional epidemiology, with mostly observational studies showing rather inconsistent results (1–3). In this ongoing debate, results of a pertinent intervention trial are potentially highly informative. In this issue of the Journal, Chlebowski et al. (4) report interim results of the Women's Intervention Nutrition Study (WINS), a low-fat dietary intervention trial among women diagnosed with breast cancer. The WINS findings, however, raise several concerns that complicate drawing etiologic conclusions about dietary fat and breast cancer as well as making definitive recommendations for survivors.

Results of the interim analysis (4) suggest a benefit of dietary fat reduction on relapse-free survival: the log-rank test was of borderline statistical significance (P = .07), and exploratory multivariable Cox regression analysis showed a . . . [Full Text of this Article]


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