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Independent Evaluation of the Gail Model
The Gail model, which predicts the absolute risk of invasive breast cancer, has been used to counsel at-risk women and design intervention studies. This model has been validated in U.S. populations, but its performance in other populations is uncertain because of variations in breast cancer rates. Decarli et al. (p. 1686) used Italian data from a casecontrol study and cancer registries to develop a new risk prediction model that uses the same risk factors as the Gail model. They tested the predictive accuracy of the two models using independent data. Both
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Cognitive Function and Breast Cancer Chemotherapy