© The Author 2006. Published by Oxford University Press.
CORRESPONDENCE |
RESPONSE: Re: IGF-1 Gene Polymorphism and Risk for Hereditary Nonpolyposis Colorectal Cancer
Affiliations of authors: The Lancet, New York, NY (MZ); Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX (CIA, MLF)
Correspondence to: Marsha L. Frazier, PhD, Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, 1155 Pressler Blvd., Unit 1365, Houston, TX 77030 (e-mail: mlfrazier@mdanderson.org).
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Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder caused by DNA mismatch repair (MMR) gene mutations with hMLH1 and hMSH2 being the most frequently mutated (1). Reeves et al. have genotyped a