© The Author 2006. Published by Oxford University Press.
CORRESPONDENCE |
Re: IGF-1 Gene Polymorphism and Risk for Hereditary Nonpolyposis Colorectal Cancer
Affiliations of authors: NBN Childhood Cancer Research Laboratory, University of Newcastle and the Hunter Medical Research Institute, Newcastle, New South Wales, Australia (SR, RJS); Division of Genetics, Hunter Area Pathology Service, John Hunter Hospital, Newcastle, New South Wales, Australia (CM, RJS)
Correspondence to: Rodney J. Scott, PhD, FRCPath, Division of Genetics, Hunter Area Pathology Service, John Hunter Hospital, Lookout Road, New Lambton, Newcastle, NSW 2305, Australia (e-mail: rodney.scott@newcastle.edu.au).
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Recently, Zecevic et al. (1) reported an association between the size of the CA-repeat sequence residing in the 5' untranslated promoter region upstream of the start site of the IGF-1 gene and age of disease onset in 121 hereditary nonpolyposis colorectal cancer patients who harbored germline mutations in the mismatch repair (MMR) genes hMLH1 or hMSH2 (1). In their study, an association between the length of the polymorphism