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JNCI Journal of the National Cancer Institute 2006 98(22):1590-1591; doi:10.1093/jnci/djj476
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© The Author 2006. Published by Oxford University Press.

EDITORIAL

Customized Diets for Cancer Prevention According to Genetic Polymorphisms: Are We Ready Yet?

Han-Yao Huang

Correspondence to: Han-Yao Huang, PhD, MPH, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St., E6144, Baltimore, MD 21205 (e-mail: hyhuang@jhsph.edu).

The first 10% of the full text of this article appears below.

Since the early 1990s, numerous studies have examined gene-gene and gene–environment interactions in relation to disease risk. Of particular interest are data on how nutrient intakes modify genetic susceptibility to diseases, which may provide scientific bases for formulating preventive strategies through dietary modification. The enthusiasm in this scientific pursuit has been put into action by entrepreneurs who sell dietary recommendations and/or dietary supplements claimed to be tailored to one's genetic susceptibility to disease. Catchy terms such as "nutrigenetic testing," "personalized supplements," "feed your genes right," and "intelligent diet" have been created and used to attract customers.

In this issue of the Journal, Lewis et al. (1) report the findings from their systematic reviews and meta-analyses of observational studies of dietary folate intake or circulating folate levels and breast cancer and of the C677T polymorphism in the . . . [Full Text of this Article]


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