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JNCI Journal of the National Cancer Institute 2006 98(22):1589-1590; doi:10.1093/jnci/djj454
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© The Author 2006. Published by Oxford University Press.

EDITORIAL

Lobular Involution: the Physiological Prevention of Breast Cancer

Donald Earl Henson, Robert E. Tarone, Hala Nsouli

Affiliations of authors: Office of Cancer Prevention and Control (DEH) and Department of Epidemiology and Biostatistics, School of Public Health and Health Services (HN), The George Washington University Cancer Institute, Washington, DC; International Epidemiology Institute, Rockville, MD (RET); Department of Medicine and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN (RET)

Correspondence to: Donald E. Henson, MD, Office of Cancer Prevention and Control, The George Washington University Cancer Institute, Ross Hall, Rm. 502, 2300 "I" St. NW, Washington, DC 20037 (e-mail: patdeh@gwumc.edu).

The first 10% of the full text of this article appears below.

It truly is a remarkable event when traditional pathologic observations lead to new ideas about the prevention of cancer. In this issue of the Journal, Milanese et al. (1), through a histologic review of breast biopsy specimens, show that the extent of age-related lobular involution is strongly associated with a reduced risk of breast cancer. Breast cancer risk decreased with increasing extent of involution in both high-risk and low-risk subgroups defined by age, epithelial atypia, reproductive history, and family history of breast cancer.

Beginning in the premenopausal period, lobular involution is a physiologic process . . . [Full Text of this Article]


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