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JNCI Journal of the National Cancer Institute 2006 98(19):1348-1349; doi:10.1093/jnci/djj406
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© The Author 2006. Published by Oxford University Press.

EDITORIAL

Chlamydia or Not Chlamydia, That Is the Question: Which Is the Microorganism Associated With MALT Lymphomas of the Ocular Adnexa?

Emanuele Zucca, Francesco Bertoni

Affiliations of authors: Lymphoma Unit and Laboratory of Experimental Oncology, Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland

Correspondence to: Emanuele Zucca, MD, Lymphoma Unit, Oncology Institute of Southern Switzerland (IOSI), Ospedale San Giovanni, CH-6500 Bellinzona, Switzerland (e-mail: emanuelezucca@yahoo.com).

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In the mid-1990s, the demonstration that Helicobacter pylori infection is a risk factor for gastric marginal-zone B-cell lymphoma of MALT type (MALT lymphoma) and the finding that eradication of these bacteria can result in histological lymphoma regression in most patients made this tumor a popular model of antigen-driven lymphomagenesis (1). The association of H. pylori with gastric MALT lymphoma led to the hypothesis that the microorganism provides an antigenic stimulus that sustains the growth of the lymphoma in the stomach, and today it is generally accepted that administration of antibiotics to eradicate H. pylori should be the sole initial treatment of gastric MALT lymphoma that is confined . . . [Full Text of this Article]


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