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JNCI Journal of the National Cancer Institute 2006 98(19):1343; doi:10.1093/jnci/djj420
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© Oxford University Press 2006.

IN THIS ISSUE

The first 10% of the full text of this article appears below.

{gamma}-Actin and Resistance to Microtubule Targeting Drugs

Acute lymphoblastic leukemia (ALL) cells resistant to microtubule-disrupting drugs express altered versions of actin. Verrills et al. (p. 1363) examined whether these altered proteins are involved in resistance to antimicrotubule agents. They found that ALL cells resistant to antimicrotubule agents expressed mutant {gamma}-actins but no wild-type {gamma}-actin. Mouse cells expressing mutant {gamma}-actin proteins were more resistant to antimicrotubule agents than cells transfected with empty plasmid, as were human neuroblastoma cells transfected with {gamma}-actin siRNA compared with mock-transfected cells. Expression of {gamma}-actin was lower in ALL samples collected at relapse than at diagnosis. . . . [Full Text of this Article]

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