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JNCI Journal of the National Cancer Institute 2006 98(15):1026-1027; doi:10.1093/jnci/djj322
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© The Author 2006. Published by Oxford University Press.

EDITORIAL

The Tango and Tangle of Human Papillomavirus and the Human Genome

Robert D. Burk, Rob DeSalle

Affiliations of authors: Departments of Microbiology and Immunology, Pediatrics, Obstetrics, Gynecology, and Women's Health, and Epidemiology and Population Health, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY (RDB); Division of Invertebrate Zoology, American Museum of Natural History, New York, NY (RD)

Correspondence to: Robert D. Burk, MD, Albert Einstein College of Medicine, Ullmann Bldg., Rm. 515, 1300 Morris Park Ave., Bronx, NY 10461 (e-mail: burk@aecom.yu.edu).

The first 10% of the full text of this article appears below.

Human papillomavirus (HPV) oncogenic types, especially type 16, are some of the most potent human carcinogens described. The odds ratio of squamous-cell cancer in HPV16-infected women has been estimated to be 435 (95% confidence interval [CI] = 278 to 679) and appears to be high throughout the world (1). The public health burden of both HPV and cervix neoplasia is profound; cervical cancer is the second most prevalent cancer in the developing world with nearly half a million cases diagnosed per year (2). In contrast, the risk of lung cancer associated with cigarette smoking varies throughout the world, with odds ratios of 4.0 and 40.0 in Japan and United States, respectively (3).

The final link in the etiologic trail of . . . [Full Text of this Article]


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