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JNCI Journal of the National Cancer Institute 2006 98(14):946-948; doi:10.1093/jnci/djj294
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© The Author 2006. Published by Oxford University Press.

EDITORIAL

Choking Hypoxia-Inducible Factor 1{alpha}: A Novel Mechanism for Connective Tissue Growth Factor Inhibition of Angiogenesis

Francesca Tosetti, Douglas M. Noonan, Adriana Albini

Affiliations of authors: Molecular Oncology Laboratory, National Cancer Research Institute, Genoa, Italy (FT, AA); University of Insubria, Varese, Italy (DMN)

Correspondence to: Adriana Albini, PhD, Ist. Nazionale per la Ricerca sul Cancro, Molecular Oncology, Largo Rosanna Benzi, 10, Genova 16132, Italy (e-mail: adriana.albini@istge.it).

The first 10% of the full text of this article appears below.

Among the driving forces that orchestrate oncogenic transformation, aberrant tumor angiogenesis has evolved as a process assured by the conscription of various signaling pathways with redundant functions. These pathways converge on the same task: to produce more vessels, without ensuring correct structural constraints and proper function. Different cellular components in tissues are equipped with proangiogenic molecular machinery, as demonstrated by studies on the role of inflammatory cells in tumor promotion that have driven the development of new therapies for cancer prevention and treatment (1,2).

Transcriptional reprogramming controlled by dysregulated signaling pathways is one of the mechanisms that are the basis for the cellular adaptations necessary for cancer establishment. In particular, one master regulator, the hypoxia-inducible transcription factor 1 (HIF-1) complex, which controls tissue homeostasis, seems to take center stage as a pervasive instigator of transformation for almost all cellular compartments in tissues.

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