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JNCI Journal of the National Cancer Institute 2006 98(13):885-887; doi:10.1093/jnci/djj286
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© Oxford University Press 2006.

NEWS

No miR Hype: MicroRNA's Cancer Role Expands

Ken Garber

The first 150 words of the full text of this article appear below.

Long considered a mere slave to DNA, carrying the genetic message from chromosomes to the protein-making machinery of the cell, RNA has come into its own.

RNA interference, discovered in 1998, is now a standard laboratory tool for knocking down gene expression. Drug therapies using small interfering RNA are now in clinical testing for treating a respiratory virus and age-related macular degeneration. And a rush of discoveries in the last 4 years have linked another class of small RNAs, known as microRNAs, to cancer. Our current knowledge of microRNAs "might be the tip of the iceberg," said Nobel Prize winner Phillip Sharp, Ph.D., of the Massachusetts Institute of Technology in Cambridge, at this year's meeting of the American Association of Cancer Research.

Research into microRNAs in cancer is exploding. MicroRNAs—miRs for short—are noncoding RNAs, about 22 nucleotides long, that bind to specific messenger RNA (mRNA) targets and either block their . . . [Full Text of this Article]

Emerging From Obscurity

New Class of Oncogenes

Arrested Development

MicroRNAs currently implicated in cancer

Detection and Treatment


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