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© Oxford University Press 2006.
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Researchers May Use Cancer Cell Lines To Identify Target Populations Prior to Clinical Trials
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In recent years, scientists have used cancer cell lines and tumor samples to decipher why one patient responds to a targeted therapy when another does not. Now several groups are doing the testing first, using their lab results to identify patients who will likely respond before a targeted therapy goes into clinical trials. For one research group, the information is already being used to select patients for an early-phase trial.
If the strategy works, clinical trials can be streamlined by these targeted therapies, requiring fewer patients and less time to show effectiveness. However, not everyone is convinced that an early choice of target populations is the right way to go, noting that it might exclude patients who would derive some benefit even if they do not show a complete response to the new drug.
Proponents say the tests will help effective drugs to get to market that might fail in
Cell Line Research Spreading
To Exclude Patients or Not
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  B. M. Veneziani, V. Criniti, C. Cavaliere, S. Corvigno, A. Nardone, S. Picarelli, G. Tortora, F. Ciardiello, G. Limite, and S. De Placido In vitro expansion of human breast cancer epithelial and mesenchymal stromal cells: optimization of a coculture model for personalized therapy approaches Mol. Cancer Ther., December 1, 2007; 6(12): 3091 - 3100. [Abstract] [Full Text] [PDF]
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