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JNCI Journal of the National Cancer Institute 2006 98(12):800-801; doi:10.1093/jnci/djj256
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© The Author 2006. Published by Oxford University Press.

EDITORIAL

A New Tumor Suppressor Gene: Invasion, Metastasis, and Angiogenesis as Potential Key Targets

Adriana Albini, Ulrich Pfeffer

Affiliations of authors: Molecular Oncology Laboratory (AA), Functional Genomics Unit (UP), National Cancer Research Institute, Genoa, Italy

Correspondence to: Adriana Albini, PhD, Ist. Nazionale per la Ricerca sul Cancro, Molecular Oncology, Largo Rosanna Benzi, 10, Genova, Italy 16132 (e-mail: adriana.albini@istge.it).

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A tumor suppressor gene is generally defined as a gene whose loss of function promotes the replication of a transformed cell. Because the loss of function yields a malignant phenotype, and in most cases deletion or inactivation of both alleles is required (1), most tumor suppressor genes have been identified through linkage analyses in cancer families or through genome-wide analyses of loss of heterozygosity (LOH) that is frequent in tumors of a specific type.

Many genes whose products influence cell growth in vitro fail this test, which makes identifying a new tumor suppressor gene perhaps one of the most daunting tasks in molecular biology. Solid in vitro evidence and supporting clinical data are required before a candidate gene can be defined as a tumor suppressor. Tsai et al. (2) present a comprehensive study that strongly . . . [Full Text of this Article]


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