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JNCI Journal of the National Cancer Institute 2006 98(12):799; doi:10.1093/jnci/djj259
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© Oxford University Press 2006.

IN THIS ISSUE

The first 10% of the full text of this article appears below.

A New Tumor Suppressor In Non–Small-Cell Lung Cancer

HLJ1 is a heat shock protein associated with tumor invasion. To determine its role in non–small-cell lung cancer, Tsai et al. (p. 825) measured its anti-tumorigenic effects in vitro and in a mouse model of lung adenocarcinoma, as well as its prognostic value in human tumors. HLJ1 expression reduced lung cancer cell proliferation, tumorigenesis, and invasion in vitro through a p53-independent pathway. HLJ1 expression was lower in human tumors than in adjacent normal tissues, and loss of heterozygosity at the HLJ1 gene locus was observed in the majority of tumors. Non–small-cell . . . [Full Text of this Article]

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