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JNCI Journal of the National Cancer Institute 2006 98(10):655; doi:10.1093/jnci/djj214
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© Oxford University Press 2006.

IN THIS ISSUE

The first 10% of the full text of this article appears below.

Pak1 Expression and Tamoxifen Resistance

Phosphorylation and activation of estrogen receptor {alpha} (ER{alpha}) by p21-activated kinase 1 (Pak1) could limit the effectiveness of antiestrogen treatment in breast cancer. Holm et al. (p. 671) evaluated Pak1 protein expression and subcellular localization in primary breast tumors from premenopausal patients who had been randomly assigned to receive 2 years of adjuvant tamoxifen or no treatment and compared tamoxifen response in relation to Pak1 and ER{alpha} expression. Among patients with ER{alpha}–positive tumors with low Pak1 expression, those treated with tamoxifen had better recurrence-free survival than those who received no treatment; . . . [Full Text of this Article]

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Lung Cancer Mortality in Never Smokers

Statin Use and Breast Cancer Risk

Recombinant Human Erythropoietins and Cancer Patients

Prostate Cancer Recurrence after Radical Prostatectomy


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