© Oxford University Press 2006.
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Pak1 Expression and Tamoxifen Resistance
Phosphorylation and activation of estrogen receptor
(ER
) by p21-activated kinase 1 (Pak1) could limit the effectiveness of antiestrogen treatment in breast cancer. Holm et al. (p. 671) evaluated Pak1 protein expression and subcellular localization in primary breast tumors from premenopausal patients who had been randomly assigned to receive 2 years of adjuvant tamoxifen or no treatment and compared tamoxifen response in relation to Pak1 and ER
expression. Among patients with ER
positive tumors with low Pak1 expression, those treated with tamoxifen had better recurrence-free survival than those who received no treatment;
Radiation Therapy and Older Patients with Breast Cancer
Lung Cancer Mortality in Never Smokers
Statin Use and Breast Cancer Risk
Recombinant Human Erythropoietins and Cancer Patients
Prostate Cancer Recurrence after Radical Prostatectomy