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JNCI Journal of the National Cancer Institute 2005 97(8):609-610; doi:10.1093/jnci/dji108
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© 2005 Oxford University Press

CORRESPONDENCE

Re: Treatment of Accidental Intrathecal Methotrexate Overdose

Sophie Gosselin, Geoffrey K. Isbister

Affiliation of authors: Department of Pharmacology and Clinical Toxicology, Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia

Correspondence to: Dr. Sophie Gosselin, Department of Clinical Pharmacology and Toxicology, Newcastle Mater Misericordiae Hospital, Level 5 Clinical Sciences Building, Waratah, NSW 2298, Australia (e-mail: sophie.gosselin@mcgill.ca).

The first 10% of the full text of this article appears below.

Widemann et al. (1) presented data on the use of cerebrospinal fluid (CSF) exchange to remove methotrexate before carboxypeptidase G2 (CPDG2) administration among patients who had an accidental intrathecal methotrexate overdose. They reported that CSF drainage removed 32%–58% of the methotrexate dose. Although they showed the percent decreases in CSF . . . [Full Text of this Article]


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Response to this Correspondence

RESPONSE: Re: Treatment of Accidental Intrathecal Methotrexate Overdose
Brigitte C. Widemann, Frank M. Balis, and Peter C. Adamson
J Natl Cancer Inst 2005 97: 610-611. [Extract] [Full Text] [PDF]