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JNCI Journal of the National Cancer Institute 2005 97(7):468-470; doi:10.1093/jnci/dji103
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© 2005 Oxford University Press

EDITORIAL

An Apple a Day...Does It Really Keep the Doctor Away? The Current State of Cancer Chemoprevention

Edward S. Kim, Waun Ki Hong

Affiliation of authors: Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas

Correspondence to: Edward S. Kim, MD, Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 432, Houston, TX 77030 (e-mail: edkim@mdanderson.org).

The first 150 words of the full text of this article appear below.

The use of natural agents as medicinal treatments has a long history. The Greek physician Hippocrates (circa 400 BCE) was one of the earliest proponents of nutritional healing. His favorite remedies were apples, dates, and barley mush (1). The term "chemoprevention," which was coined in 1976 (2), describes the use of specific natural, synthetic, or biologic agents to reverse, suppress, or prevent the development of disease.

Chemoprevention is an appealing approach to treating patients with a variety of medical conditions. For instance, cardiac patients who take low-dose aspirin do so in hopes of preventing a future ischemic event. Cancer chemoprevention's best model is early-stage breast cancer, for which hormonal agents are used to prevent recurrence and contralateral disease in patients with the appropriate hormone receptor status.

Both basic biologic research and clinical chemical intervention are the underpinnings of chemoprevention aimed at delaying or halting the . . . [Full Text of this Article]


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