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JNCI Journal of the National Cancer Institute 2005 97(6):406-407; doi:10.1093/jnci/dji086
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© 2005 Oxford University Press

EDITORIAL

Radiotherapy for Breast Cancer

Jack Cuzick

Correspondence to: Jack Cuzick, PhD, Cancer Research-UK, Centre for Epidemiology, Mathematics & Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London, EC1M 6BQ, United Kingdom (e-mail: jack.cuzick@cancer.org.uk).

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The role of radiotherapy in the treatment of breast cancer has a long and controversial history. One of the first clinical trials ever performed, beginning in 1949, studied this question (1,2), and it remains the subject of new trials that are still being initiated today. Early trials clearly demonstrated that radiotherapy reduced local relapse, with a relative risk reduction that is now known to be about 70%. However, the reduction in relapse rates did not translate to a reduction in mortality. Many . . . [Full Text of this Article]


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