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JNCI Journal of the National Cancer Institute 2005 97(5):402; doi:10.1093/jnci/dji075
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© 2005 Oxford University Press

CORRESPONDENCE

RESPONSE: Re: Determinants of BRAF Mutations in Primary Melanomas

J. L. Maldonado, J. Fridlyand, B. C. Bastian

Affiliations of authors: Department of Dermatology (JLM, BCB), Department of Epidemiology and Biostatistics (JF), UCSF Comprehensive Cancer Center (JF, BCB), and Department of Pathology (BCB), University of California, San Francisco

Correspondence to: B. C. Bastian, MD, Departments of Dermatology and Pathology, P.O. Box 0808, University of California at San Francisco, San Francisco, CA 94143 (e-mail: bastian@cc.ucsf.edu).

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We respond with interest to Dr. Purdue's commentary raising two important issues about our observation that not all melanomas with an associated nevus arise from melanocytes with BRAF mutations. He correctly points out that we could have missed preexisting nevi in some of our melanomas, because the melanomas included in our analysis were relatively thick and, therefore, could have overgrown a nevus that was present earlier in the . . . [Full Text of this Article]


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Related Correspondence

Re: Determinants of BRAF Mutations in Primary Melanomas
Mark P. Purdue
J Natl Cancer Inst 2005 97: 401-402. [Extract] [Full Text] [PDF]