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JNCI Journal of the National Cancer Institute 2005 97(5):325; doi:10.1093/jnci/97.5.325
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© 2005 Oxford University Press

IN THIS ISSUE

The first 10% of the full text of this article appears below.

EGFR Gene Mutations in Lung Cancers

To clarify the role of mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancer pathogenesis, Shigematsu et al. (p. 339) sequenced the EGFR TK domain of non–small-cell lung cancers (NSCLCs), normal lung tissue samples, and other epithelial cancers from patients in Japan, Taiwan, the United States, and Australia. They found an EGFR TK domain mutation in 21% of the NSCLCs but not in nonmalignant lung tissue from the same patients or in the other carcinomas. EGFR TK domain mutations were more frequent in never smokers versus . . . [Full Text of this Article]

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